Studies on 1,1 ́-(4,6-dihydroxy-1,3-phenylene)diethanone based bischalcones and flavones
نویسندگان
چکیده
Resorcinol based bis-chalcones (2a-d) and flavones (3a-d) were synthesized and evaluated for their antimicrobial activity. Bis-chalcones (2a-d) were prepared by condensing 1,1 ́-(4,6-dihydroxy-1,3-phenylene)diethanone (1) with appropriate aryl-aldehydes, oxidative cyclization of bis-chalcones in presence of iodine gave corresponding flavones (3a-d). The synthesized compounds were evaluated for their antimicrobial actions against some selected bacterial and fungal strains. One compound, 1-{2,4-dihydroxy-5-[3-(2,4-dichlorophenyl)-2-propenoyl]phenyl}-3(2,4-dichlorophenyl)-2-propen-1-one (2d), emerged as lead compound with significant antimicrobial activities.
منابع مشابه
Bis-chalcones and flavones: synthesis and antimicrobial activity.
A series of bis-chalcones (3a-g) and their flavones derivatives (4a-g) were synthesized and evaluated for their antimicrobial activity. Bis-chalcones were prepared by condensing 1,1'-(4,6-dihydroxy-1,3-phenylene)diethanone (2) with appropriate aryl aldehydes following Claisen-Schmidt reaction conditions. Oxidative cyclization of bis-chalcones (3a-g) in DMSO in the presence of iodine furnished f...
متن کاملA novel antioxidant isobenzofuranone derivative from fungus Cephalosporium sp.AL031.
Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihy...
متن کاملSynthesis and Characterization of Some New Tetraaldehyde and Tetraketone Derivatives and X-ray Structure of 1,1′-(4,4′-(2-(1,3-bis(4-Acetylphenoxy)propan-2-ylidene)propane-1,3-di-yl)bis(oxy)bis(4,1-phenylene))diethanone
Tetraketone and tetraaldehyde derivatives 2a-d were synthesized via the reaction of ethene-1,1,2,2,-tetra-yl-tetramethylene tetrabromide (1) with hydroxyketone and aldehyde derivatives. The molecular structures were identified by IR, (1)H-NMR, (13)C-NMR and MS analysis. The crystal structure of the title compound 2a, C(38)H(36)O(8), is reported. Its crystal data are: monoclinic, space group P 2...
متن کاملComputational and electrochemical studies on the redox reaction of 2-(2,3-dihydroxy phenyl)-1,3- dithiane in aqueous solution
Electrode potential of 2-(2,3-dihydroxy phenyl)-1,3-dithiane (DPD) was investigated by means of cyclic voltammetry (CV) at various potential scan rates. The calculated value was compared with the experimental value obtained by cyclic voltammetry (CV). All experiments were done in aqueous phosphate buffer solutions at different pHs. The experimental redox potential of DPD was obtained to be 0.75...
متن کاملTwo new flavones from Tridax procumbens Linn.
Two new flavones, 8,3'-dihydroxy-3,7,4'-trimethoxy-6-O-β-D-glucopyranosyl flavone (1) and 6,8,3'-trihydroxy-3,7,4'-trimethoxyflavone (2) were isolated from Tridax procumbens Linn., together with the four known compounds puerarin (3), esculetin (4), oleanolic acid (5) and betulinic acid (6). The structures of the two new flavones were elucidated based on chemical analysis and spectral methods (I...
متن کامل